|
KMID : 0613820130230070904
|
|
Journal of Life Science
2013 Volume.23 No. 7 p.904 ~ p.912
|
|
|
Effect of Cordycepin-increased Cordyceps militaris Powder on Tissues Lipid Peroxidation and Antioxidative Activity in Carbon Tetrachloride-induced Hepatic Damage in Rats
|
|
Ahn Hee-Young
Park Kyu-Rim
Kim Yu-Ra
Cha Jae-Young
Cho Young-Su
|
|
|
Abstract
|
|
|
|
This study aimed to evaluate the protective effect of cordycepin-increased Cordyceps militaris strain on carbon tetrachloride (CCI₄)-induced hepatotoxicity and oxidative stress in rats. Male Sprague-Dawley rats were randomly divided into five groups (n=6) based on six dietary categories: normal (N), CCI₄ control (C), CCI₄ plus Paecilomyces japonica (CPJ) (3%, w/w), CCI₄ plus C. militaris (CCM) (3%, w/w), and CCI₄ plus cordycepin-increased C. militaris (CCMα) (3%, w/w). The activities of the liver marker enzymes ALT, AST, and LDH and the levels of lipid peroxidation were increased in the CCI₄-treated groups, but these parameters were significantly decreased in the CCMα group. The TBARS content in the liver homogenate, microsome, and mitochondrial fractions of the C group was significantly elevated compared with the N group. However, in the CCI₄-treated groups, CCMα group was significantly lowered in the TBARS levels of hepatic homogenate and microsomal fractions. The C group showed a significant decrease in the levels of plasma and hepatic glutathione, whereas they were significantly increased in the CCMα group. Accordingly, cordycepin-increased C. militaris may be an ideal animal model for studying hepatoprotective effects.
|
|
|
KEYWORD
|
|
|
Cordyceps militaris, Paecilomyces japonica, cordycepin, carbon tetrachloride (CCI₄), hepatotoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|